Issue 23, 2011
From the journal:

Chemical Communications

A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles†

Xufeng Lin,*a   Zhenjun Mao,a   Xixiang Dai,a   Ping Lua  and  Yanguang Wang*a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, H, China
E-mail: lxfok@zju.edu.cn, orgwyg@zju.edu.cn

Abstract

Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.

Graphical abstract: A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles

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Article information

DOI
https://doi.org/10.1039/C1CC11363A
Article type
Communication
Submitted
09 Mar 2011
Accepted
15 Apr 2011
First published
12 May 2011

Chem. Commun., 2011,47, 6620-6622

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A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles

X. Lin, Z. Mao, X. Dai, P. Lu and Y. Wang, Chem. Commun., 2011, 47, 6620 DOI: 10.1039/C1CC11363A

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