Novel chiral recognition beyond the limitation due to the law of mass action: highly enantioselective chiral sensing based on non-linear response in phase transition events

Abstract

Based on non-linear response in phase transition events exhibiting a sharp transmittance change, an intelligent chiral sensor capable of chirality amplification in aqueous media was designed and constructed as poly(N-isopropylacrylamide) having chiral pseudo-18-crown-6. Both sensitivity and selectivity of the sensor surmount the limitation due to the law of mass action.