Issue 30, 2011
From the journal:

Chemical Communications

Recognition of thymine in DNA bulges by a Zn(ii) macrocyclic complex†

Imee Marie A. del Mundo,a   Matthew A. Fountainab  and  Janet R. Morrow*a  

* Corresponding authors

a Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, USA
E-mail: jmorrow@buffalo.edu
Fax: 716-645-6963
Tel: 716-645-4187

b Department of Chemistry and Biochemistry, State University of New York, College at Fredonia, Fredonia, USA
E-mail: matthew.fountain@fredonia.edu
Tel: 716-673-3287

Abstract

A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(II) complex bound to the thymine bulge.

Graphical abstract: Recognition of thymine in DNA bulges by a Zn(ii) macrocyclic complex

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Article information

DOI
https://doi.org/10.1039/C1CC12074C
Article type
Communication
Submitted
12 Apr 2011
Accepted
31 May 2011
First published
27 Jun 2011

Chem. Commun., 2011,47, 8566-8568

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Recognition of thymine in DNA bulges by a Zn(II) macrocyclic complex

I. M. A. del Mundo, M. A. Fountain and J. R. Morrow, Chem. Commun., 2011, 47, 8566 DOI: 10.1039/C1CC12074C

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