Issue 26, 2011
From the journal:

Chemical Communications

Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex†

Meng Zhao,a   Han-Lu Wang,a   Li Zhang,a   Cunyuan Zhao,a   Liang-Nian Jia  and  Zong-Wan Mao*a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
E-mail: cesmzw@mail.sysu.edu.cn
Fax: +86-20-84112245
Tel: +86-20-84113788

Abstract

A surprisingly low pKa (4.3) for a Cu(II) bridging water was found in the presented complex, Cu22L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn22L at typical lysosomal pH (∼5.0).

Graphical abstract: Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex

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Article information

DOI
https://doi.org/10.1039/C1CC12466H
Article type
Communication
Submitted
27 Apr 2011
Accepted
20 May 2011
First published
03 Jun 2011

Chem. Commun., 2011,47, 7344-7346

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Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex

M. Zhao, H. Wang, L. Zhang, C. Zhao, L. Ji and Z. Mao, Chem. Commun., 2011, 47, 7344 DOI: 10.1039/C1CC12466H

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