Issue 33, 2011
From the journal:

Chemical Communications

A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge†

N. Qi,‡a   K. Jung,‡b   M. Wang,a   L. X. Na,a   Z. J. Yang,*a   L. R. Zhang,a   A. H. Guseb  and  L. H. Zhang*a  

* Corresponding authors

a State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
E-mail: zdszlh@bjmu.edu.cn and yangzj@bjmu.edu.cn

b Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

Abstract

A concise method for the formation of cyclopyrophosphate of cIDPRE as well as sulfur and selenium-substituted pyrophosphate cIDPRE analogues (P1S-cIDPRE, P1Se-cIDPRE, P2S-cIDPRE and P2Se-cIDPRE) was reported and one of the PS-diastereoisomers, P1S-cIDPRE-1, is a novel membrane-permeant cADPR antagonist.

Graphical abstract: A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge

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Article information

DOI
https://doi.org/10.1039/C1CC13062E
Article type
Communication
Submitted
25 May 2011
Accepted
12 Jul 2011
First published
22 Jul 2011

Chem. Commun., 2011,47, 9462-9464

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A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge

N. Qi, K. Jung, M. Wang, L. X. Na, Z. J. Yang, L. R. Zhang, A. H. Guse and L. H. Zhang, Chem. Commun., 2011, 47, 9462 DOI: 10.1039/C1CC13062E

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