Issue 40, 2011
From the journal:

Chemical Communications

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase†

Avgousta Ioannou,a   Elena Cini,b   Roxana S. Timofte,b   Sabine L. Flitsch,*a   Nicholas J. Turner*a  and  Bruno Linclau*b  

* Corresponding authors

a MIB & School of Chemistry, The University of Manchester, 131 Princess Street, Manchester, UK
E-mail: sabine.flitsch@manchester.ac.uk, nicholas.turner@manchester.ac.uk
Fax: +44 (0) 161 2751311
Tel: +44 (0) 161 3065172/5173

b School of Chemistry, University of Southampton, Highfield, Southampton, UK
E-mail: bruno.linclau@soton.ac.uk
Fax: +44 (0)23 8059 3781
Tel: +44 (0)23 8059 3816

Abstract

Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar.

Graphical abstract: Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC13956H
Article type
Communication
Submitted
02 Jul 2011
Accepted
22 Aug 2011
First published
13 Sep 2011

Chem. Commun., 2011,47, 11228-11230

Permissions

Request permissions

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

A. Ioannou, E. Cini, R. S. Timofte, S. L. Flitsch, N. J. Turner and B. Linclau, Chem. Commun., 2011, 47, 11228 DOI: 10.1039/C1CC13956H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements