Issue 6, 2011
From the journal:

Organic & Biomolecular Chemistry

New synthetic route to N-tocopherol derivatives: synthesis of pyrrolopyridinol analogue of α-tocopherol from pyridoxine†

Tae-gyu Nam,‡ab   Jin-Mo Ku,‡bc   Hyeung-geun Park,c   Ned A. Porter*a  and  Byeong-Seon Jeong*d  

* Corresponding authors

a Department of Chemistry, Vanderbilt University, Nashville, USA.
E-mail: n.porter@vanderbilt.edu
Fax: +1-615-343-5478
Tel: +1-615-343-2693

b Gyeonggi Bio-Center, Suwon, Republic of Korea

c Research Institute of Pharmaceutical Science and College of Pharmacy, Seoul National University, Republic of Korea

d College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea
E-mail: jeongb@ynu.ac.kr
Fax: +82-53-810-4654
Tel: +82-53-810-2814

Abstract

A new synthetic route to pyrrolopyridinol antioxidants from easily accessible pyridoxine was developed which includes phase-transfer catalytic alkylation and intramolecular Cu(I)-catalyzed amination as key steps.

Graphical abstract: New synthetic route to N-tocopherol derivatives: synthesis of pyrrolopyridinol analogue of α-tocopherol from pyridoxine

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Article information

DOI
https://doi.org/10.1039/C0OB00991A
Article type
Paper
Submitted
08 Nov 2010
Accepted
02 Dec 2010
First published
03 Dec 2010

Org. Biomol. Chem., 2011,9, 1749-1755

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New synthetic route to N-tocopherol derivatives: synthesis of pyrrolopyridinol analogue of α-tocopherol from pyridoxine

T. Nam, J. Ku, H. Park, N. A. Porter and B. Jeong, Org. Biomol. Chem., 2011, 9, 1749 DOI: 10.1039/C0OB00991A

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