Issue 10, 2011
From the journal:

Organic & Biomolecular Chemistry

A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm†

Xin Liu,a   Yuming Sun,b   Yuanhong Zhang,a   Fang Miao,a   Guancong Wang,a   Hongshi Zhao,a   Xiaoqiang Yu,*a   Hong Liu*a  and  Wai-Yeung Wong*c  

* Corresponding authors

a State Key Laboratory of Crystal Materials, Shandong University, Jinan, P. R. China
E-mail: yuxq@sdu.edu.cn, hongliu@sdu.edu.cn
Fax: 0531-88366418
Tel: 0531-88366418

b School of Information Science and Engineering, Shandong University, Jinan, P. R. China

c Areas of Excellence Scheme (University Grants Committee, Hong Kong) and Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, P. R. China
E-mail: rwywong@hkbu.edu.hk
Fax: (+ 852)3411-7348

Abstract

A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl-4-vinylpyridinium iodine)-N-ethylcarbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI.

Graphical abstract: A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

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Article information

DOI
https://doi.org/10.1039/C1OB05123G
Article type
Communication
Submitted
22 Jan 2011
Accepted
21 Feb 2011
First published
22 Feb 2011

Org. Biomol. Chem., 2011,9, 3615-3618

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A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

X. Liu, Y. Sun, Y. Zhang, F. Miao, G. Wang, H. Zhao, X. Yu, H. Liu and W. Wong, Org. Biomol. Chem., 2011, 9, 3615 DOI: 10.1039/C1OB05123G

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