Issue 10, 2011
From the journal:

Organic & Biomolecular Chemistry

Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water†‡

Masaharu Ueno,a   Taku Kitanosono,a   Masaru Sakaia  and  Shū Kobayashi*a  

* Corresponding authors

a Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: shu_kobayashi@chem.s.u-tokyo.ac.jp
Fax: (+81)-3-5684-0634

Abstract

Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)3–chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.

Graphical abstract: Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water

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Article information

DOI
https://doi.org/10.1039/C1OB05424D
Article type
Communication
Submitted
22 Feb 2011
Accepted
18 Mar 2011
First published
18 Mar 2011

Org. Biomol. Chem., 2011,9, 3619-3621

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Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water

M. Ueno, T. Kitanosono, M. Sakai and S. Kobayashi, Org. Biomol. Chem., 2011, 9, 3619 DOI: 10.1039/C1OB05424D

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