Issue 9, 2011
From the journal:

Organic & Biomolecular Chemistry

Rapid synthesis of bis(hetero)aryls by one-pot Masuda borylation–Suzuki coupling sequence and its application to concise total syntheses of meridianins A and G†‡§

Eugen Merkul,a   Elisabeth Schäfera  and  Thomas J. J. Müller*a  

* Corresponding authors

a Lehrstuhl für Organische Chemie, Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Düsseldorf, Germany
E-mail: ThomasJJ.Mueller@uni-duesseldorf.de
Fax: +49 0211 8114324
Tel: +49 0211 8112298

Abstract

3-(Hetero)aryl substituted indoles, 7-azaindoles, and pyrroles can be obtained in a very concise fashion via a one-pot Masuda borylation–Suzuki coupling sequence. The concise total syntheses of the marine natural products meridianins A (5) and G (4i) nicely illustrate the utility of this methodology.

Graphical abstract: Rapid synthesis of bis(hetero)aryls by one-pot Masuda borylation–Suzuki coupling sequence and its application to concise total syntheses of meridianins A and G

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Article information

DOI
https://doi.org/10.1039/C1OB05310H
Article type
Communication
Submitted
02 Dec 2010
Accepted
25 Feb 2011
First published
28 Feb 2011

Org. Biomol. Chem., 2011,9, 3139-3141

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Rapid synthesis of bis(hetero)aryls by one-pot Masuda borylation–Suzuki coupling sequence and its application to concise total syntheses of meridianins A and G

E. Merkul, E. Schäfer and T. J. J. Müller, Org. Biomol. Chem., 2011, 9, 3139 DOI: 10.1039/C1OB05310H

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