Issue 10, 2011

Enantioselective organocatalytic Michael-hemiketalization catalyzed by a trans-bifunctional indanethioureacatalyst

Abstract

An efficient, convenient and enantioselective Michael-hemiketalization reaction has been developed for the synthesis of naphthoquinones. In this work, a novel trans-bifunctional indane thiourea catalyst has been reported to promote this process to afford high yields (up to 99%) and high to excellent enantiomeric excesses (90–98% ee).

Graphical abstract: Enantioselective organocatalytic Michael-hemiketalization catalyzed by a trans-bifunctional indane thiourea catalyst

Supplementary files

Article information

Article type
Paper
Submitted
15 Mar 2011
Accepted
23 Mar 2011
First published
23 Mar 2011

Org. Biomol. Chem., 2011,9, 3691-3697

Enantioselective organocatalytic Michael-hemiketalization catalyzed by a trans-bifunctional indane thiourea catalyst

Y. Gao, Q. Ren, S. Ang and J. Wang, Org. Biomol. Chem., 2011, 9, 3691 DOI: 10.1039/C1OB05404J

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