Issue 22, 2011
From the journal:

Organic & Biomolecular Chemistry

Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex†

Hiromichi Egami,ab   Shinji Kamisuki,ab   Kosuke Dodo,ab   Miwako Asanuma,ab   Yoshitaka Hamashimab  and  Mikiko Sodeoka*ab  

* Corresponding authors

a Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology, 2-1 Hirosawa, Wako-shi, Saitama, Japan
E-mail: sodeoka@riken.jp
Fax: 81 48 462 4666

b RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, Japan

Abstract

A cobalt–phosphine complex supported on PS-PEG beads was found to react with a propargyl carbamate tag, and the tagged molecules immobilized on the beads could be released by acidic treatment through the Nicholas reaction pathway. These reactions work in aqueous media at 4 °C, so that this catch and release procedure is compatible with conditions generally used in biochemical experiments.

Graphical abstract: Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB06123B
Article type
Communication
Submitted
08 Jul 2011
Accepted
18 Aug 2011
First published
19 Aug 2011

Org. Biomol. Chem., 2011,9, 7667-7670

Permissions

Request permissions

Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex

H. Egami, S. Kamisuki, K. Dodo, M. Asanuma, Y. Hamashima and M. Sodeoka, Org. Biomol. Chem., 2011, 9, 7667 DOI: 10.1039/C1OB06123B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements