Issue 22, 2011
From the journal:

Organic & Biomolecular Chemistry

Synthesis and activity of the archazolid western hemisphere†

Ann B. Tran,a   Geoffrey C. Melly,a   Ryan Doucette,b   Brook Ashcraft,b   Leanne J. Sebren,a   Nathan Havko,b   Jeffery C. Youngb  and  Gregory W. O'Neil*a  

* Corresponding authors

a Department of Chemistry, Western Washington University, Bellingham, WA, USA
E-mail: oneil@chem.wwu.edu
Fax: 01 360 650 2826
Tel: 01 360 650 6283

b Department of Biology, Western Washington University, Bellingham, WA, USA

Abstract

A convergent and scalable synthesis of the archazolid western hemisphere has been completed. The V-ATPase inhibitory activity of this compound along with a previously prepared eastern domain was then tested using a convenient Arabidopsis-based V-ATPase assay.

Graphical abstract: Synthesis and activity of the archazolid western hemisphere

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Article information

DOI
https://doi.org/10.1039/C1OB06446K
Article type
Communication
Submitted
23 Aug 2011
Accepted
05 Sep 2011
First published
07 Sep 2011

Org. Biomol. Chem., 2011,9, 7671-7674

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Synthesis and activity of the archazolid western hemisphere

A. B. Tran, G. C. Melly, R. Doucette, B. Ashcraft, L. J. Sebren, N. Havko, J. C. Young and G. W. O'Neil, Org. Biomol. Chem., 2011, 9, 7671 DOI: 10.1039/C1OB06446K

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