Issue 25, 2012
From the journal:

Chemical Communications

A reversible near-infrared fluorescence probe for reactive oxygen species based on Te–rhodamine†

Yuichiro Koide,‡a   Mitsuyasu Kawaguchi,‡a   Yasuteru Urano,b   Kenjiro Hanaoka,a   Toru Komatsu,a   Masahiro Abo,a   Takuya Teraia  and  Tetsuo Nagano*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Japan
E-mail: tlong@mol.f.u-tokyo.ac.jp
Fax: +81 3 5841 4855
Tel: +81 3 5841 4850

b Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Japan

Abstract

We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo.

Graphical abstract: A reversible near-infrared fluorescence probe for reactive oxygen species based on Te–rhodamine

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Article information

DOI
https://doi.org/10.1039/C2CC18011A
Article type
Communication
Submitted
22 Dec 2011
Accepted
06 Feb 2012
First published
07 Feb 2012

Chem. Commun., 2012,48, 3091-3093

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A reversible near-infrared fluorescence probe for reactive oxygen species based on Te–rhodamine

Y. Koide, M. Kawaguchi, Y. Urano, K. Hanaoka, T. Komatsu, M. Abo, T. Terai and T. Nagano, Chem. Commun., 2012, 48, 3091 DOI: 10.1039/C2CC18011A

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