Issue 47, 2012

Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas

Abstract

A three-component cascade reaction of salicylaldehyde, malononitrile/cyanoacetate and nitromethane catalysed by chiral tertiary amino-thioureas was developed, which leads to the production of highly functionalized 2-amino-4H-chromenes in good yields with good to excellent enantioselectivities.

Graphical abstract: Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas

Supplementary files

Article information

Article type
Communication
Submitted
02 Feb 2012
Accepted
17 Apr 2012
First published
09 May 2012

Chem. Commun., 2012,48, 5880-5882

Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas

G. Yang, C. Luo, X. Mu, T. Wang and X. Liu, Chem. Commun., 2012, 48, 5880 DOI: 10.1039/C2CC30731F

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