Issue 59, 2012
From the journal:

Chemical Communications

A universal platform for amplified multiplexed DNA detection based on exonuclease III-coded magnetic microparticle probes†

Ming Luo,a   Xia Xiang,a   Dongshan Xiang,a   Si Yang,a   Xinghu Jia  and  Zhike He*a  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: zhkhe@whu.edu.cn
Fax: +86-27-6875-4067
Tel: +86-27-6875-6557

Abstract

An amplified multiplexed DNA detection biosensor has been developed, which combines the unique cleavage function of exonuclease III (Exo III) with the separating ability of magnetic microparticles (MMPs). By using different fluorophores, the multiplexed detection of DNA is demonstrated.

Graphical abstract: A universal platform for amplified multiplexed DNA detection based on exonuclease III-coded magnetic microparticle probes

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Article information

DOI
https://doi.org/10.1039/C2CC33249C
Article type
Communication
Submitted
06 May 2012
Accepted
31 May 2012
First published
08 Jun 2012

Chem. Commun., 2012,48, 7416-7418

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A universal platform for amplified multiplexed DNA detection based on exonuclease III-coded magnetic microparticle probes

M. Luo, X. Xiang, D. Xiang, S. Yang, X. Ji and Z. He, Chem. Commun., 2012, 48, 7416 DOI: 10.1039/C2CC33249C

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