Issue 70, 2012

A target-activated autocatalytic DNAzyme amplification strategy for the assay of base excision repair enzyme activity

Abstract

Based on a target-activated autocatalytic DNAzyme amplification strategy, novel fluorescence sensing platforms were constructed for highly sensitive and selective assay of base excision repair enzyme activity. By using a rolling circle amplification (RCA)-coupled amplification cascade, an extremely low detection limit (0.002 U mL−1) was achieved.

Graphical abstract: A target-activated autocatalytic DNAzyme amplification strategy for the assay of base excision repair enzyme activity

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2012
Accepted
16 Jul 2012
First published
17 Jul 2012

Chem. Commun., 2012,48, 8820-8822

A target-activated autocatalytic DNAzyme amplification strategy for the assay of base excision repair enzyme activity

L. Zhang, J. Zhao, J. Jiang and R. Yu, Chem. Commun., 2012, 48, 8820 DOI: 10.1039/C2CC34531E

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