Issue 81, 2012
From the journal:

Chemical Communications

Light-regulated host–guest interaction as a new strategy for intracellular PEG-detachable polyplexes to facilitate nuclear entry†

Wenyu Li,a   Youxiang Wang,*a   Lina Chen,a   Zhixiong Huang,a   Qiaoling Hua  and  Jian Jia  

* Corresponding authors

a MOE key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: yx_wang@zju.edu.cn
Fax: +86 571 87953726
Tel: +86 571 87953726

Abstract

PEG-detachable polyplexes were constructed for the first time via host–guest interactions between β-cyclodextrin and azobenzene. The polyplexes had excellent colloidal stability and competition stability. Moreover, the intracellular light-regulated dePEGylation facilitated DNA release and nuclear entry, thus resulting in efficient transfection.

Graphical abstract: Light-regulated host–guest interaction as a new strategy for intracellular PEG-detachable polyplexes to facilitate nuclear entry

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Article information

DOI
https://doi.org/10.1039/C2CC34768G
Article type
Communication
Submitted
04 Jul 2012
Accepted
24 Aug 2012
First published
28 Aug 2012

Chem. Commun., 2012,48, 10126-10128

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Light-regulated host–guest interaction as a new strategy for intracellular PEG-detachable polyplexes to facilitate nuclear entry

W. Li, Y. Wang, L. Chen, Z. Huang, Q. Hu and J. Ji, Chem. Commun., 2012, 48, 10126 DOI: 10.1039/C2CC34768G

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