Issue 78, 2012
From the journal:

Chemical Communications

Intracellular self-assembly of nanoparticles for enhancing cell uptake†

Qingqing Miao,a   Xiaoyu Bai,a   Yingying Shen,b   Bin Mei,a   Jinhao Gao,c   Li Lib  and  Gaolin Liang*ac  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, P. R. China
E-mail: gliang@ustc.edu.cn
Fax: +86-551-3600730
Tel: +86-551-3607935

b State Key Laboratory of Oncology in Southern China, Imaging Diagnostic and Interventional Center, Cancer Center, Sun Yet-sen University, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China

c The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, 361005, P. R. China

Abstract

A radioactive probe (1) has been developed and applied to a condensation reaction and self-assembly of radioactive nanoparticles (i.e., 125I-NPs) intracellularly. Upon 160 min cellular efflux, the radioactivity retained in cells incubated with 1 was 4-fold more higher than that of those cells treated with a scrambled control probe (1-Scr).

Graphical abstract: Intracellular self-assembly of nanoparticles for enhancing cell uptake

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Article information

DOI
https://doi.org/10.1039/C2CC34899C
Article type
Communication
Submitted
09 Jul 2012
Accepted
17 Aug 2012
First published
20 Aug 2012

Chem. Commun., 2012,48, 9738-9740

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Intracellular self-assembly of nanoparticles for enhancing cell uptake

Q. Miao, X. Bai, Y. Shen, B. Mei, J. Gao, L. Li and G. Liang, Chem. Commun., 2012, 48, 9738 DOI: 10.1039/C2CC34899C

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