A simple and universal quencher-free molecular beacon (MB) with low background fluorescence is developed based on an intermolecular G-quadruplex signaling probe. Unlike previous fluorescent MB strategies, it can function without any fluorophore and quencher modifications on its hairpin sequence.
H. Zhou, S. Xie, J. Li, Z. Wu and G. Shen, Chem. Commun., 2012, 48, 10760 DOI: 10.1039/C2CC35964B
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