Issue 6, 2012

Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

Abstract

A phthalocyaninechalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(II) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.

Graphical abstract: Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

Supplementary files

Article information

Article type
Communication
Submitted
28 Oct 2011
Accepted
24 Nov 2011
First published
04 Jan 2012

Org. Biomol. Chem., 2012,10, 1154-1157

Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

S. Tuncel, J. Fournier-dit-Chabert, F. Albrieux, V. Ahsen, S. Ducki and F. Dumoulin, Org. Biomol. Chem., 2012, 10, 1154 DOI: 10.1039/C2OB06809E

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