Issue 12, 2012

Direct O-glycosidation of resin bound thioglycosides

Abstract

The application of the safety-catch linker concept to solid-phase glycoconjugate synthesis is described. The process allows for direct conjugation of resin bound glycans to complex aglycones during cleavage. Large excesses of either coupling partner are not required, and even very hindered alcohols serve as acceptors in the reaction.

Graphical abstract: Direct O-glycosidation of resin bound thioglycosides

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2011
Accepted
19 Dec 2011
First published
20 Dec 2011

Org. Biomol. Chem., 2012,10, 2373-2376

Direct O-glycosidation of resin bound thioglycosides

S. H. Nguyen, A. H. Trotta, J. Cao, T. J. Straub and C. S. Bennett, Org. Biomol. Chem., 2012, 10, 2373 DOI: 10.1039/C2OB06883D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements