Intramolecular chiral communication in peptide–dendron hybrids

Abstract

The conformational properties of a series of peptide–dendron hybrids progressively incorporating 1–4 dendritic side chains were investigated by circular dichroism. Although the presence of multiple adjacent dendrons along the peptide backbone precluded the formation of α-helical or β-sheet secondary structure, intramolecular packing of the dendrons mediated efficient peptide → dendron chirality transfer in both organic and aqueous media.