Issue 10, 2012
From the journal:

RSC Advances

Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols†

Simon Drescher,*ab   Susan Becker,a   Bodo Dobnera  and  Alfred Blumeb  

* Corresponding authors

a Institute of Pharmacy, Wolfgang-Langenbeck-Str. 4, Halle/Saale, Germany
E-mail: simon.drescher@pharmazie.uni-halle.de
Fax: +49(0) 345 5527026
Tel: +49(0) 345 5525196

b Institute of Chemistry, von-Danckelmann-Platz 4, Halle/Saale, Germany

Abstract

The synthesis of long-chain, phenylene-modified 1,ω-diols can be effectively performed in 60% overall yield using the bis-Sonogashira cross-coupling with 6 mol% of PdCl2(PPh3)2 and tetrabutylammonium fluoride in a copper-, amine- and solvent-free setting followed by hydrogenation.

Graphical abstract: Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

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Article information

DOI
https://doi.org/10.1039/C2RA20411H
Article type
Communication
Submitted
06 Mar 2012
Accepted
08 Mar 2012
First published
09 Mar 2012

RSC Adv., 2012,2, 4052-4054

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Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

S. Drescher, S. Becker, B. Dobner and A. Blume, RSC Adv., 2012, 2, 4052 DOI: 10.1039/C2RA20411H

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