Issue 16, 2013

Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction

Abstract

Using the bianalyte method we unambiguously demonstrate that a single gold nanosphere on a metal film junction, in the so-called nanoparticle on a mirror configuration, is capable of single molecule detection with surface-enhanced Raman spectroscopy (SERS). Also this configuration serves as a convenient and highly sensitive SERS sensor for detection of biomolecules. Such simple nano-junction based systems are ideal for chemical and biomedical analysis.

Graphical abstract: Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction

Supplementary files

Article information

Article type
Paper
Submitted
05 Mar 2013
Accepted
29 Apr 2013
First published
02 May 2013

Analyst, 2013,138, 4574-4578

Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction

L. Li, T. Hutter, U. Steiner and S. Mahajan, Analyst, 2013, 138, 4574 DOI: 10.1039/C3AN00447C

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