Issue 16, 2013

Selection of a representative matrix for the multiresidue analysis of nine β-agonists in animal tissues and urine with LC-MS/MS

Abstract

In the determination of nine β-agonists including salbutamol, terbutaline, cimaterol, fenoterol, clorprenaline, ractopamine, tulobuterol, clenbuterol and penbuterol in porcine, bovine, lamb and chicken muscle, liver and urine samples with LC-MS/MS, calibration curves prepared in solvent (SC) were compared with those prepared in each matrix (MC) for all analytes. Significant differences (P < 0.05) between SC and each MC for most analytes indicated the existence of matrix effects and the necessity of using MC for quantitation to compensate MEs. Then MC in each muscle, liver and urine sample was compared with the select potential representative matrix, followed by validating the recoveries of nine analytes calculated through the MC in the potential representative matrix and MC in their corresponding matrices, respectively. The results suggested that porcine muscle could be selected as a representative matrix to calibrate β-agonist residues in bovine, lamb and chicken muscle samples.

Graphical abstract: Selection of a representative matrix for the multiresidue analysis of nine β-agonists in animal tissues and urine with LC-MS/MS

Article information

Article type
Paper
Submitted
05 Dec 2012
Accepted
13 May 2013
First published
15 May 2013

Analyst, 2013,138, 4579-4584

Selection of a representative matrix for the multiresidue analysis of nine β-agonists in animal tissues and urine with LC-MS/MS

L. Wang, L. He, Z. Wang, X. Wang, J. Shu, J. Yang, G. Zhang and Z. Zeng, Analyst, 2013, 138, 4579 DOI: 10.1039/C3AN36806H

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