Issue 13, 2013
From the journal:

Chemical Communications

Targeting cancer cells with controlled release nanocapsules based on a single aptamer†

Frank J. Hernandez,‡a   Luiza I. Hernandez,‡a   Alessandro Pinto,b   Thomas Schäferbc  and  Veli C. Özalp*de  

* Corresponding authors

a Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA 52242, USA

b NanoBioSeparations Group, POLYMAT, University of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San Sebastián, Spain

c Ikerbasque, Basque Foundation for Science, Bilbao, Spain

d Nanobiz Ltd. Metu Technopolis, 06800 Ankara, Turkey

e Middle East Technical University, Biological Sciences, 06800 Ankara, Turkey
E-mail: cozalp@metu.edu.tr
Tel: +90 312 444 6266

Abstract

Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion.

Graphical abstract: Targeting cancer cells with controlled release nanocapsules based on a single aptamer

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Article information

DOI
https://doi.org/10.1039/C2CC37370J
Article type
Communication
Submitted
09 Oct 2012
Accepted
20 Dec 2012
First published
21 Dec 2012

Chem. Commun., 2013,49, 1285-1287

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Targeting cancer cells with controlled release nanocapsules based on a single aptamer

F. J. Hernandez, L. I. Hernandez, A. Pinto, T. Schäfer and V. C. Özalp, Chem. Commun., 2013, 49, 1285 DOI: 10.1039/C2CC37370J

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