Issue 44, 2013
From the journal:

Chemical Communications

A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide†

Ajay A. Sathe,a   Douglas R. Hartlinea  and  Alexander T. Radosevich*a  

* Corresponding authors

a Department of Chemistry, The Pennsylvania State University, University Park, USA
E-mail: radosevich@psu.edu
Tel: +1 814 867 4268

Abstract

A method for the synthesis of α-amino acids by direct reductive carboxylation of aromatic imines with CO2 is described. The protocol employs readily available commercial reagents and serves as a one-step alternative to the Strecker synthesis.

Graphical abstract: A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide

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Article information

DOI
https://doi.org/10.1039/C3CC42057D
Article type
Communication
Submitted
21 Mar 2013
Accepted
16 Apr 2013
First published
25 Apr 2013

Chem. Commun., 2013,49, 5040-5042

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A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide

A. A. Sathe, D. R. Hartline and A. T. Radosevich, Chem. Commun., 2013, 49, 5040 DOI: 10.1039/C3CC42057D

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