Issue 50, 2013
From the journal:

Chemical Communications

Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines†

Yu-Tao He,a   Lian-Hua Li,a   Yan-Fang Yang,a   Yu-Qi Wang,a   Jian-Yi Luo,a   Xue-Yuan Liua  and  Yong-Min Liang*a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
E-mail: liangym@lzu.edu.cn
Fax: +86-931-8912582

Abstract

A mild and efficient copper-catalyzed trifluoromethylation reaction which involves the cyclization of oximes has been developed. This method provides a convenient access to a variety of useful CF3-containing 4,5-dihydroisoxazoles by constructing a C–CF3 bond and a C–O bond in one step.

Graphical abstract: Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

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Article information

DOI
https://doi.org/10.1039/C3CC42588F
Article type
Communication
Submitted
09 Apr 2013
Accepted
03 May 2013
First published
03 May 2013

Chem. Commun., 2013,49, 5687-5689

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Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

Y. He, L. Li, Y. Yang, Y. Wang, J. Luo, X. Liu and Y. Liang, Chem. Commun., 2013, 49, 5687 DOI: 10.1039/C3CC42588F

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