Issue 50, 2013
From the journal:

Chemical Communications

An environmentally sensitive fluorescent purine nucleoside that changes emission wavelength upon hybridization†

Yoshio Saito,*a   Azusa Suzuki,a   Yuji Okada,a   Yuki Yamasaka,a   Nobukatsu Nemotoa  and  Isao Saito*b  

* Corresponding authors

a Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan
E-mail: saitoy@chem.ce.nihon-u.ac.jp
Fax: +81 (0)24 956 8924
Tel: +81 (0)24 956 8809

b NEWCAT Institute, College of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan

Abstract

C7-naphthylethynylated 8-aza-7-deaza-2′-deoxyguanosine naG was synthesized and its photophysical properties were examined. The fluorescent nucleoside exhibited solvatofluorochromic properties (Δλflmax = 67 nm). An ODN probe containing naG forms a stable base pair only with C and discriminates structural changes such as mismatches and deletions by a distinct change in its emission wavelength.

Graphical abstract: An environmentally sensitive fluorescent purine nucleoside that changes emission wavelength upon hybridization

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Article information

DOI
https://doi.org/10.1039/C3CC42605J
Article type
Communication
Submitted
10 Apr 2013
Accepted
01 May 2013
First published
02 May 2013

Chem. Commun., 2013,49, 5684-5686

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An environmentally sensitive fluorescent purine nucleoside that changes emission wavelength upon hybridization

Y. Saito, A. Suzuki, Y. Okada, Y. Yamasaka, N. Nemoto and I. Saito, Chem. Commun., 2013, 49, 5684 DOI: 10.1039/C3CC42605J

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