Issue 70, 2013

Silver cations fold i-motif at neutral pH

Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used acidic conditions to fold the DNA. Herein we describe the use of silver cations to fold an i-motif forming DNA sequence at physiological pH. Subsequent DNA unfolding can be achieved by chelation with cysteine.

Graphical abstract: Silver cations fold i-motif at neutral pH

Supplementary files

Article information

Article type
Communication
Submitted
10 May 2013
Accepted
16 Jul 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 7696-7698

Silver cations fold i-motif at neutral pH

H. A. Day, C. Huguin and Z. A. E. Waller, Chem. Commun., 2013, 49, 7696 DOI: 10.1039/C3CC43495H

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