Issue 82, 2013
From the journal:

Chemical Communications

G-quadruplex unfolding in higher-order DNA structures†

Iolanda Fotticchia,a   Concetta Giancola*b  and  Luigi Petraccone*c  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, Fisciano (SA), Italy

b Dipartimento di Farmacia, Università di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy
E-mail: giancola@unina.it

c Dipartimento di Scienze Chimiche Università di Napoli “Federico II”, Via Cintia 4, 80126 Napoli, Italy
E-mail: luigi.petraccone@unina.it

Abstract

G-quadruplex unfolding within a sequence of two quadruplex units was characterized by gel electrophoresis, calorimetry and spectroscopy. The obtained results suggest that the kinetics and thermodynamics of the individual quadruplex unfolding are affected by its interaction with other DNA secondary structural elements.

Graphical abstract: G-quadruplex unfolding in higher-order DNA structures

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Article information

DOI
https://doi.org/10.1039/C3CC44560G
Article type
Communication
Submitted
18 Jun 2013
Accepted
16 Aug 2013
First published
19 Aug 2013

Chem. Commun., 2013,49, 9488-9490

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G-quadruplex unfolding in higher-order DNA structures

I. Fotticchia, C. Giancola and L. Petraccone, Chem. Commun., 2013, 49, 9488 DOI: 10.1039/C3CC44560G

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