Issue 93, 2013
From the journal:

Chemical Communications

Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery†

Li Yan,ab   Wei Chen,ab   Xiaoyue Zhu,ab   Longbiao Huang,ab   Zhigang Wang,c   Guangyu Zhu,c   V. A. L. Roy,ab   K. N. Yua  and  Xianfeng Chen*ab  

* Corresponding authors

a Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, China
E-mail: xianfeng.chen@cityu.edu.hk
Fax: +852-34420538
Tel: +852-34427813

b Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Hong Kong SAR, China

c Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, China

Abstract

Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.

Graphical abstract: Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/C3CC45714A
Article type
Communication
Submitted
26 Jul 2013
Accepted
02 Oct 2013
First published
02 Oct 2013

Chem. Commun., 2013,49, 10938-10940

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Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

L. Yan, W. Chen, X. Zhu, L. Huang, Z. Wang, G. Zhu, V. A. L. Roy, K. N. Yu and X. Chen, Chem. Commun., 2013, 49, 10938 DOI: 10.1039/C3CC45714A

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