Palladium catalyzed dehydrogenative arylation of coumarins: an unexpected switch in regioselectivity†
Abstract
A new regioselective α-arylation of coumarins with unactivated simple arenes via a palladium-catalyzed twofold C–H functionalization is devised. This method offers an attractive new approach to synthesis of a wide variety of 3-arylcoumarins from readily accessible starting materials.