Issue 5, 2013
From the journal:

Chemical Science

Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array†

S. Gokhan Elci,‡a   Daniel F. Moyano,‡a   Subinoy Rana,a   Gulen Yesilbag Tonga,a   Ronnie L. Phillips,b   Uwe H. F. Bunzc  and  Vincent M. Rotello*a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA
E-mail: rotello@chem.umass.edu
Fax: +1-413-545-2058
Tel: +1-413-545-4490

b School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA

c Organisch-Chemisches Institut, Ruprecht-Karls-Universität, Im Neuenheimer Feld 270, 69120 Heidelberg, FRG

Abstract

A sensor array composed of eight functionalized gold nanoparticles and a fluorescent polymer was utilized to identify 11 glycosaminoglycans (GAGs) by their chemical signatures. Particle ligand structure was key in differentiating analytes, with aromatic and specific sugar functionalities recognizing GAG structural parameters including sulfonation, acetylation, epimeric structure, size, and charge.

Graphical abstract: Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3SC22279A
Article type
Edge Article
Submitted
19 Dec 2012
Accepted
01 Mar 2013
First published
01 Mar 2013

Chem. Sci., 2013,4, 2076-2080

Permissions

Request permissions

Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array

S. G. Elci, D. F. Moyano, S. Rana, G. Y. Tonga, R. L. Phillips, U. H. F. Bunz and V. M. Rotello, Chem. Sci., 2013, 4, 2076 DOI: 10.1039/C3SC22279A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements