Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release

Hong Ren; Lingyu Zhang; Jiping An; Tingting Wang; Lu Li; Xiaoyan Si; Liu He; Xiaotong Wu; Chungang Wang; Zhongmin Su

doi:10.1039/C3CC47666A

Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release†

Hong Ren,^a Lingyu Zhang,^a Jiping An,^b Tingting Wang,*^c Lu Li,^a Xiaoyan Si,^a Liu He,^a Xiaotong Wu,^a Chungang Wang*^a and Zhongmin Su*^a

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* Corresponding authors

^a Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China
E-mail: wangcg925@nenu.edu.cn, zmsu@nenu.edu.cn

^b Hospital of Stomatology, JiLin University, Changchun 130021, P. R. China

^c School of Chemistry & Environmental Engineering, Changchun University of Science and Technology, Changchun, P. R. China
E-mail: wangtt@cust.edu.cn

Abstract

The polyacrylic acid@zeolitic imidazolate framework-8 (PAA@ZIF-8) nanoparticles (NPs) were first fabricated using a facile and simple route. It is worthwhile noting that the as-fabricated PAA@ZIF-8 NPs possessed ultrahigh doxorubicin (DOX) loading capability (1.9 g DOX g⁻¹ NPs), which were employed as pH-dependent drug delivery vehicles.

Chemical Communications

Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release†

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Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release

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