Issue 11, 2014
From the journal:

Chemical Communications

Gold catalysed synthesis of 3-alkoxyfurans at room temperature†

Matthew N. Pennell,a   Robert W. Foster,a   Peter G. Turner,b   Helen C. Hailes,a   Christopher J. Tameb  and  Tom D. Sheppard*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon St, London, UK
E-mail: tom.sheppard@ucl.ac.uk
Fax: +44 (0)7679 7463
Tel: +44 (0)7679 2467

b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, UK

Abstract

Synthetically important 3-alkoxyfurans can be prepared efficiently via treatment of acetal-containing propargylic alcohols (obtained from the addition of 3,3-diethoxypropyne to aldehydes) with 2 mol% gold catalyst in an alcohol solvent at room temperature. The resulting furans show useful reactivity in a variety of subsequent transformations.

Graphical abstract: Gold catalysed synthesis of 3-alkoxyfurans at room temperature

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Article information

DOI
https://doi.org/10.1039/C3CC48290A
Article type
Communication
Submitted
29 Oct 2013
Accepted
11 Dec 2013
First published
18 Dec 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 1302-1304

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Gold catalysed synthesis of 3-alkoxyfurans at room temperature

M. N. Pennell, R. W. Foster, P. G. Turner, H. C. Hailes, C. J. Tame and T. D. Sheppard, Chem. Commun., 2014, 50, 1302 DOI: 10.1039/C3CC48290A

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