Issue 30, 2014
From the journal:

Chemical Communications

Development of the crosslinking reactions to RNA triggered by oxidation†

Shuhei Kusano,a   Takuya Haruyama,a   Shogo Ishiyama,a   Shinya Hagiharab  and  Fumi Nagatsugi*a  

* Corresponding authors

a Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Japan
E-mail: nagatugi@tagen.tohoku.ac.jp
Tel: +81-22-217-5633

b Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan

Abstract

A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.

Graphical abstract: Development of the crosslinking reactions to RNA triggered by oxidation

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Article information

DOI
https://doi.org/10.1039/C3CC49463B
Article type
Communication
Submitted
13 Dec 2013
Accepted
18 Feb 2014
First published
18 Feb 2014

Chem. Commun., 2014,50, 3951-3954

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Development of the crosslinking reactions to RNA triggered by oxidation

S. Kusano, T. Haruyama, S. Ishiyama, S. Hagihara and F. Nagatsugi, Chem. Commun., 2014, 50, 3951 DOI: 10.1039/C3CC49463B

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