Issue 21, 2014
From the journal:

Chemical Communications

Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening†

Qin Wu,‡abc   Dan Gao,‡bc   Juntong Wei,abc   Feng Jin,b   Weiyi Xie,abc   Yuyang Jiang*abd  and  Hongxia Liu*bc  

* Corresponding authors

a Department of Chemistry, Tsinghua University, Beijing, China

b State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

c Key Laboratory of Metabolomics at Shenzhen, Shenzhen, China
E-mail: liuhx@sz.tsinghua.edu.cn
Fax: +86-755-26036035
Tel: +86-755-26036035

d Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China
E-mail: jiangyy@sz.tsinghua.edu.cn
Fax: +86-755-26036017
Tel: +86-755-26036017

Abstract

A novel multi-layer microfluidic device was developed for characterization of drug metabolism in human liver microsomes (HLMs) and their cytotoxicity on cells. The results demonstrated that this platform is robust for low levels of compounds and shows potential for high-throughput drug screening in drug development.

Graphical abstract: Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening

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Article information

DOI
https://doi.org/10.1039/C3CC49771B
Article type
Communication
Submitted
25 Dec 2013
Accepted
17 Jan 2014
First published
30 Jan 2014

Chem. Commun., 2014,50, 2762-2764

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Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening

Q. Wu, D. Gao, J. Wei, F. Jin, W. Xie, Y. Jiang and H. Liu, Chem. Commun., 2014, 50, 2762 DOI: 10.1039/C3CC49771B

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