We report the effect of DNA-templation on aniline-catalyzed N-acylhydrazone formation. The reaction occurs in both two-component and three-component systems. Through systematic catalyst modifications, we are able to increase the efficiency of the DNA-templated variant to 85-fold above that of the uncatalyzed reaction at physiological pH.
D. W. Domaille and J. N. Cha, Chem. Commun., 2014, 50, 3831 DOI: 10.1039/C4CC00292J
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