A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2–24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
H. M.-F. Viart, T. S. Larsen, C. Tassone, T. L. Andresen and M. H. Clausen, Chem. Commun., 2014, 50, 7800 DOI: 10.1039/C4CC00863D
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