A self-assembled conformational switch: a host–guest stabilized triple stem molecular beacon via a photoactivated and thermal regeneration mode

Abstract

We present a novel strategy for construction of a conformational switch of a molecular beacon based on the combination of nucleic acid (DNA) self-assembly and reversible host–guest inclusion interaction. With the functionalized probe, the nucleic acid hybridization process can be easily controlled with a photoactivated and thermal regeneration mode.