Issue 58, 2014
From the journal:

Chemical Communications

Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing†

Hangxiang Wang,‡a   Wei Chen,‡b   Haiyang Xie,a   Xuyong Wei,a   Shengyong Yin,a   Lin Zhou,a   Xiao Xu*a  and  Shusen Zheng*a  

* Corresponding authors

a First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China
E-mail: zjxu@zju.edu.cn, shusenzheng@zju.edu.cn

b Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China

Abstract

Chimeric peptides composed of arginine-rich RNA-binding and tumor cell-targeting motifs have been employed to condense siRNA to form supramolecular nanoparticles via electrostatic associations and deliver siRNA agents in a tumor cell-specific manner.

Graphical abstract: Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

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Article information

DOI
https://doi.org/10.1039/C4CC01061B
Article type
Communication
Submitted
10 Feb 2014
Accepted
12 May 2014
First published
12 May 2014

Chem. Commun., 2014,50, 7806-7809

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Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

H. Wang, W. Chen, H. Xie, X. Wei, S. Yin, L. Zhou, X. Xu and S. Zheng, Chem. Commun., 2014, 50, 7806 DOI: 10.1039/C4CC01061B

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