EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Lijun Jiang; Yin-Lai Lui; Hongguang Li; Chi-Fai Chan; Rongfeng Lan; Wai-Lun Chan; Terrence Chi-Kong Lau; George Sai-Wah Tsao; Nak-Ki Mak; Ka-Leung Wong

doi:10.1039/C4CC01589D

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells†

Lijun Jiang,^a Yin-Lai Lui,^b Hongguang Li,^a Chi-Fai Chan,^a Rongfeng Lan,^c Wai-Lun Chan,^a Terrence Chi-Kong Lau,^d George Sai-Wah Tsao,^e Nak-Ki Mak*^b and Ka-Leung Wong*^a

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* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR
E-mail: klwong@hkbu.edu.hk
Tel: +852-34112370

^b Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR
E-mail: nkmak@hkbu.edu.hk
Tel: +852-34117059

^c Institute of Research and Continuing Education, Hong Kong Baptist University, Shenzhen, P. R. China

^d Department of Biology and Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR

^e Department of Anatomy, The University of Hong Kong, Hong Kong SAR

Abstract

An EBNA1-specific small molecule (JLP₂) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP₂ may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

Chemical Communications

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells†

Abstract

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EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

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