We have developed a folate receptor-specific activatable probe for in vivo near-infrared fluorescence imaging of ovarian cancer. This probe becomes highly fluorescent only when its linker is cleaved by a tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
H. Lee, J. Kim, H. Kim, Y. Kim and Y. Choi, Chem. Commun., 2014, 50, 7507 DOI: 10.1039/C4CC02301C
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