Issue 78, 2014
From the journal:

Chemical Communications

Postsynthetic modification of an amino-tagged MOF using peptide coupling reagents: a comparative study†

Henrik Hintza  and  Stefan Wuttke*a  

* Corresponding authors

a Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany
E-mail: stefan.wuttke@cup.uni-muenchen.de

Abstract

The suitability of four peptide coupling reagents for postsynthetic modification (PSM) of amino-tagged metal–organic frameworks (MOFs) with carboxylic acids was investigated. Mild reaction conditions at room temperature allow effective covalent attachment of drugs and biomolecules inside the pores of MOFs with moderate chemical stability.

Graphical abstract: Postsynthetic modification of an amino-tagged MOF using peptide coupling reagents: a comparative study

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Article information

DOI
https://doi.org/10.1039/C4CC02650K
Article type
Communication
Submitted
10 Apr 2014
Accepted
12 Jun 2014
First published
18 Jun 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 11472-11475

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Postsynthetic modification of an amino-tagged MOF using peptide coupling reagents: a comparative study

H. Hintz and S. Wuttke, Chem. Commun., 2014, 50, 11472 DOI: 10.1039/C4CC02650K

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