We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.
V. S. R. Harrison, C. E. Carney, K. W. Macrenaris and T. J. Meade, Chem. Commun., 2014, 50, 11469 DOI: 10.1039/C4CC05651E
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