Issue 65, 2014
From the journal:

Chemical Communications

Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids†

Vincent J. Venditto,a   Aaron Dolor,a   Aditya Kohli,b   Stefan Salentinig,c   Ben J. Boydc  and  Francis C. Szoka, Jr.*ab  

* Corresponding authors

a Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, USA

b The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
E-mail: szoka@cgl.ucsf.edu

c Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria 3052, Australia

Abstract

We describe a new class of charge inverted zwitterionic sulfated lipids (AS) with a cationic quaternary amine anchored at the membrane interface and an anionic sulfate moiety extended into the aqueous phase. These lipids have exceptionally high transition temperatures and assemble into lipid aggregates when dispersed in aqueous solutions.

Graphical abstract: Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids

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Article information

DOI
https://doi.org/10.1039/C4CC02866J
Article type
Communication
Submitted
17 Apr 2014
Accepted
20 Jun 2014
First published
23 Jun 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 9109-9111

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Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids

V. J. Venditto, A. Dolor, A. Kohli, S. Salentinig, B. J. Boyd and F. C. Szoka, Chem. Commun., 2014, 50, 9109 DOI: 10.1039/C4CC02866J

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