Issue 67, 2014
From the journal:

Chemical Communications

Detection of cancer cells using triplex DNA molecular beacons based on expression of enhanced green fluorescent protein (eGFP)†

Dongmei Xi,a   Xindong Wang,b   Shiyun Aib  and  Shusheng Zhang*a  

* Corresponding authors

a Shandong Province Key Laboratory of Detection Technology for Tumor Makers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China
E-mail: shushzhang@126.com
Fax: +86-539-8766867
Tel: +86-539-8766867

b College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018, P. R. China

Abstract

A novel strategy was proposed for Ramos cell detection by combining the expression of enhanced green fluorescent protein (eGFP) with the cell aptamer recognition and the triplex molecular beacons. This system was successfully applied to cancer cell detection with high sensitivity and specificity.

Graphical abstract: Detection of cancer cells using triplex DNA molecular beacons based on expression of enhanced green fluorescent protein (eGFP)

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Article information

DOI
https://doi.org/10.1039/C4CC03925D
Article type
Communication
Submitted
22 May 2014
Accepted
01 Jul 2014
First published
04 Jul 2014

Chem. Commun., 2014,50, 9547-9549

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Detection of cancer cells using triplex DNA molecular beacons based on expression of enhanced green fluorescent protein (eGFP)

D. Xi, X. Wang, S. Ai and S. Zhang, Chem. Commun., 2014, 50, 9547 DOI: 10.1039/C4CC03925D

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