Issue 69, 2014
From the journal:

Chemical Communications

A novel fluorescence probe for estimation of cysteine/histidine in human blood plasma and recognition of endogenous cysteine in live Hct116 cells†

Upendar Reddy G.,a   Hridesh Agarwalla,a   Nandaraj Taye,b   Suvankar Ghorai,b   Samit Chattopadhyay*b  and  Amitava Das*a  

* Corresponding authors

a Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune-411008, India
E-mail: a.das@ncl.res.in
Fax: +91 2025902629
Tel: +91 2025902385

b Chromatin and Disease Biology Lab, National Centre for Cell Science, Pune 411007, India
E-mail: samit@nccs.res.in

Abstract

A new Cu(II)-complex is used as a “Turn-On” luminescence probe for specific detection of endogenous Cys in live Hct116 cells and Cys present in human blood plasma without any interference from other amino acids, especially GSH and Hcy. Difference in the mechanistic pathway for Cys and His recognition is discussed.

Graphical abstract: A novel fluorescence probe for estimation of cysteine/histidine in human blood plasma and recognition of endogenous cysteine in live Hct116 cells

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Article information

DOI
https://doi.org/10.1039/C4CC04214J
Article type
Communication
Submitted
02 Jun 2014
Accepted
02 Jul 2014
First published
03 Jul 2014

Chem. Commun., 2014,50, 9899-9902

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A novel fluorescence probe for estimation of cysteine/histidine in human blood plasma and recognition of endogenous cysteine in live Hct116 cells

U. R. G., H. Agarwalla, N. Taye, S. Ghorai, S. Chattopadhyay and A. Das, Chem. Commun., 2014, 50, 9899 DOI: 10.1039/C4CC04214J

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